Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Article Abstract:

Hypoxia causes the oncogenic cell selection with a reduction in apoptotic tendency, and makes them resistant to cancer therapy drugs. An over-expression of the Bcl-2 protein that suppresses the cell death, and the removal of p53 tumor-suppressor gene, decrease the cell death due to hypoxia. Transplanted tumors expressing wild-type p53 are regions that have hypoxia and high rates of cell death, but tumors in hypoxic regions that lack p53 are less apoptotic. The oncogenic transformation of cells makes them more sensitive to a decrease in oxygen content.

Physiological aspects, Observations, Hypoxia, Anoxia, Tumors, Cell transformation

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p53 is required for radiation-induced apoptosis in mouse thymocytes

Article Abstract:

The wild type of p53 tumor suppressor gene can induce cell death or apoptosis when introduced into cell lines which have lost endogenous p53 function. Although self-reactive thymocytes go through negative selection by apoptosis during normal development, it is not clearly understood how apoptosis is induced by other stimuli. The function of p53 in apoptosis of mouse thymocytes was investigated. Results indicated that p53 was essential for radiation-induced apoptosis in the thymus but not for all forms of apoptosis.

Cancer, Cancer genetics

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A microRNA component of the p53 tumor suppressor network

Article Abstract:

A study of microRNA function in tumor suppression revealed that p53 network suppresses tumor formation and miR-34 along with other effectors inhibits cell proliferation.

United States, Science & research, DNA damage, RNA, Oncogenes, Structure, T cell proliferation, Tumour suppressor genes

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