Identification of the homologous beige and Chediak-Higashi syndrome genes

Article Abstract:

Mutant beige (bg) mice and human Chediak-Higashi syndrome patients exhibit homologous disorders related to Lyst mutations. The candidate gene, Lyst, encodes a protein with a carboxy-terminal prenylation motif and multiple potential phosphorylation sites. A direct complementary DNA selection from a yeast artificial chromosome clone identifies Lyst. This gene is disrupted by deletions in bg mice with the messenger RNA losing bg homozygotes. Lyst protein has the ability to form helical domains and displays similarity to coiled-coil phosphoprotein, stathmin, in its sequences.

Research, Gene mutations, Gene mutation, Mice, mutant strains, Mutant mice, Chediak-Higashi syndrome

---

Cytokine receptor signalling

Article Abstract:

The signalling activity of cytokine receptors requires the association of the receptors with one or more members of a once obscure family termed the Janus kinases (JAKs). The JAK molecules link the binding of ligands to tyrosine phosphorylation of signalling proteins. The cytokine receptors stimulate signalling pathways using phosphotyrosine. The membrane-distal and the membrane-proximal regions of the receptors are necessary for signalling. The haematopoietic cell phosphatase inhibits the activity of these receptors while phosphatase Syp increases the activity.

Observations, Proteins, Cell receptors, Cytokines, Tyrosine, Cell physiology

---

Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription

Article Abstract:

The use of the isoquinoline sulphonamide derivative H-8, which is a potent inhibitor of CTD kinase, proves that basal transcription occurs in the absence of phosphorylation of c-terminal domain (CTD) of RNA polymerse II.

Similar abstracts:

• Abstracts: Interaction of the erythropoietin and stem-cell-factor receptors. The meaning of life
• Abstracts: Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene. Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice
• Abstracts: Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Two nuclear signalling pathways for vitamin D
• Abstracts: Sequential allocation of offspring sexes in the hyperparasitoid wasp, Dendrocerus carpenteri. Appetitive olfactory learning in Drosophila larvae: Effects of repetition, reward strength, age, gender, assay type and memory span
• Abstracts: Separation of chiral phases in monolayer crystals of racemic amphiphiles. Asymmetric autocatalysis and amplification of enantiomeric excess of a chiral molecule

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.