In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

Article Abstract:

An in vivo genetic fate-mapping strategy, using a Gli1 (GLI-Kruppel family member) as a sensitive readout of sonic hedgehog (Shh) activity is adopted, to systematically mark and follow the fate of Shh-responding cells in the adult mouse forebrain. Results reveal that initially, only a small population of cells responds to Shh in regions undergoing neurogenesis.

Brain cells

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At the root of brain cancer

Article Abstract:

Brain cancers are among the most devastating tumours in humans and are often rapidly fatal despite aggressive treatments. A small subpopulation of brain-cancer stem cells is identified in humans, and they have the exclusive ability to drive tumour formation, and could prove an effective target for therapies.

Brain cancer

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To be and not to be

Article Abstract:

The molecular basis of asymmetric division of stem cells is investigated. The model for probabilistic mechanism of self-renewal of stereotypical stem cells, with their predictable pattern of division is discussed.

Structure

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