Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
Article Abstract:
The LIM homeodomain protein ISL1 is expressed in all classes of islet cells in the adult and in mesenchymal cells that surround the dorsal evagination of the gut endoderm, which partly comprise the pancreatic anlagen. Acinar and islet cell differentiation in mice deficient in ISL1 function was analyzed to define the role of ISL1 in the development of pancreas. Results show that ISL1 is required in the development of the dorsal exocrine pancreas while its function in pancreatic endodermal cells is needed for the generation of all endocrine islet cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Notch signalling controls pancreatic cell differentiation
Article Abstract:
Pancreatic endocrine cells share certain molecular characteristics with neurons. Pancreas development in mice genetically altered at several steps in the Notch signalling pathway was analyzed. Mice deficient for Delta-like gene 1 (Dll1) or the intracellular mediator RBP-JK exhibited accelerated differentiation of pancreatic endocrine cells. Ngn3 is found to act as pro-endocrine gene and Notch signalling is essential for the decision between the endocrine and progenitor fates within the pancreas.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Attenuation of FGF signalling in mouse B-cells leads to diabetes
Article Abstract:
Type 2 diabetes is the inability of pancreatic B-cells to produce adequate amounts of insulin when required. The role of fibroblast growth factor in the development of the pancreas and its connection with diabetes is assessed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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