Induction of the growth inhibitor IGF-binding protein 3 by p53

Article Abstract:

The transgene p53 controls activity of the gene which encodes the insulin-like growth factor binding protein 3 (IGF-BP3). The induction of IGF-BP3 gene expression by wild-type p53 is associated with enhanced secretion of an active form of IGF-BP3. Such a secretion prevents mitogenic signalling by the insulin-like growth factor IGF-1. Stimulation of p53 gene in EB1 colon carcinoma cells increases the concentration of mRNA encoding the IGF-BP3. Results show that IGF-BP3 is involved in the cell growth controlled by p53.

Analysis, Physiological aspects, Cell death, Tumor suppressor genes, Insulin-like growth factors, Somatomedins

---

Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2

Article Abstract:

Transcription factors with basic helix-loop-helix (HLF) motifs are essential for certain cell differentiation processes during multicellular organism development. The functions of the transcription factors are inhibited by Id proteins, by suppression of their heterodimerization partners vial the HLH domains. Id2 is found to be essential for normal development of mice, and is require for the generation of peripheral lymphoid organs and NK cells.

Cell proliferation

---

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

Article Abstract:

The Hedgehog signalling pathway is required for tissue development during embryogenesis. Hedgehog-interacting protein (Hip) is a novel component identified in the vertebrate signalling pathway. It can bind Hedgehog proteins by encoding a membrane glycoprotein. A model where Hip attenuates Hedgehog signalling due to binding to Hedgehog proteins is supported by the findings.

Similar abstracts:

• Abstracts: Distinct functions for the two importin subunits in nuclear protein import. PDBBrowse - a graphics interface to the Brookhaven Protein Data Bank
• Abstracts: Mapping to the point. Lights turning red on amber. Dynamo model at a turning point
• Abstracts: Modulation of neuronal activity by target uncertainty. Playing the trump card of uncertainty. Uncertainty over complementarity?
• Abstracts: Revealing the hidden costs of research. UCSF settles lawsuit over research costs

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.