Infection breaks T-cell tolerance

Article Abstract:

Infection with the nematode Nippostrongylus brasiliensis (N. brasiliensis) disrupts the immunological T-cell tolerance in mice brought on by injection with the Staphylococcus enterotoxin B (SEB). N. brasiliensis infection of mice broke down SEB-related tolerance primarily by expanding the SEB-tolerant CD4+V-beta-8+ T cells in vivo. Hence the activation of anergic, potentially autoreactive CD4+ T cells by infectious agents may be involved in the development of autoimmune diseases.

Research, Enterotoxins, Nematoda, Nematodes, Immunological tolerance, Immunologic tolerance

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Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

Article Abstract:

Tests of the T-cell response in mice clarified how immunization with myelin basic protein (MBP) can trigger onset of experimental allergic encephalomyelitis (EAE), a T-cell mediated autoimmune disease. MBP peptides that remain cryptic during primary immunization were changed to dominant determinants of immunological status as EAE progressed. This discovery may improve understanding of the pathogenesis and treatment of EAE and other T-cell-controlled autoimmune diseases.

Care and treatment, Myelin proteins, Encephalomyelitis, Autoantigens

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Twins and T-cell responses

Article Abstract:

A new study of T-cell responses in twins shows that when only one twin has multiple sclerosis, the twins have different T-cell receptor repertoires for specific antigens. This is further evidence of the role non-genetic factors play in autoimmune disease. Longitudinal studies of affected individuals, and studies of other autoimmune diseases and T-cell receptor repertoires, would be appropriate.

Twins

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