Inhibitory long-term potentiation underlies auditory conditioning of goldfish escape behaviour
Article Abstract:
Long-term potentiation (LTP) is often seen as a cellular model for learning and memory. The model validity assumes that physiological stimuli can induce LTP in vivo and the synaptic modifications that result correlate with behavioural changes. The goldfish Mauthner (M)-cell has been used for electrophysiological studies, and it has previously been shown that tetanic stimulation can induce LTP of the synapses controlling the M-cell excitability. It is now reported that potentiation of the inhibitory connection resembling the LTP induced by afferent tetanization can be induced by natural sensory stimulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Smad4 and FAST-1 in the assembly of activin-responsive factor
Article Abstract:
TGF-beta signalling molecules activate transmembrane receptors , phosphorylating and activating SMADs, signal transducers. Smad2 participates in an activin-responsive factor (ARF) in frog embryos. The main DNA-binding component of ARF is FAST-1, which has a novel winged-helix structure. Smad4 is also present in ARF, and results of an experiment show that Smad4 stabilizes a Smad2-FAST-1 complex as a DNA-binding factor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Feedback from inhibitory SMADs
Article Abstract:
The transforming growth factor-beta (TGF-beta) superfamily are involved in a number of biological processes, including those involved with cell proliferation. Past studies of the SMAD family of signal transducers have helped to show how TGF-beta signals are mediated by intracellular pathways. New studies show that some SMADs can inhibit, rather than mediate, TGF-beta signalling. Details of the studies are presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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