Interaction between the retinoblastoma protein and the oncoprotein MDM2
Article Abstract:
Retinoblastoma proteins and p53 growth can be negatively regulated by the product of a single cellular proto-oncogene. The major factor for human tumorigenesis is the inactivation of tumor-suppressor genes which leads to deregulated cell proliferation. Both p53 and retinoblastoma genes in the inactivation form, which are targeted and inactivated by three distinct DNA tumor virus groups, are observed in human tumors. The cellular oncoprotein in human homologue, MDM2, interacts with pRB and p53 through interference with their growth regulatory functions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha
Article Abstract:
The transcription of cellular antiviral defense genes occurs when the transcription factor ISGF3, consisting of Stat1, Stat2 and p48, transduces interferon-alpha (IFN-A). Adenovirus E1A hinders the IFN-A's response, making unhindered viral replication possible. E1A targets p300 and CREB-binding proteins (CBP), which in turn, interacts specifically with Stat2. E1A's interacts with p300 and CBP represses Stat2 transactivation amd IFN-A-activated transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Article Abstract:
Analysis of p300, a cellular protein indicates its homology with the nuclear protein CBP and its function as a transcription initiator, implying that p300 and CBP are members of transcriptional adaptor protein family. E1A oncoprotein inhibits the stimulation of transcription by these proteins. CBP, which exists in a complex form, reacts with E1A, causing transcription initiation inhibition.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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