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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

A structural change in the kinesin motor protein that drives motility

Article Abstract:

It has been possible to directly measure conformation of the kinesin neck linker in different nucleotide- and microtubule-binding states. This has formed the basis for a structural model of how kinesin moves along a microtubule. Fluorescence resonance energy transfer indicates that the neck linker experiences a large motion directed towards the tip of the catalytic core when microtubule-bound kinesin binds an ATP analogue. It was possible to devise a model for how ATP-induced neck linker docking can drive kinesin motility.

Author: Vale, Ronald D., Cooke, Roger, Taylor, Edwin W., Naber, Nariman, Milligan, Ronald A., Rice, Sarah, Wilson-Kubalek, Elizabeth M., Whittaker, Michael, Hart, Cynthia L., Lin, Abel W., Safer, Daniel, Cain, Shane M., Carragher, Bridget O., Pechatnikova, Elena, Pate, Edward
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999

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Direction determination in the minus-end-directed kinesin motor ncd

Article Abstract:

Kinesin superfamily motor proteins transport intracellular matter along microtubules. The ncd 'neck' comprising 13 class specific residues next to the superfamily-conserved catalytic core, is found to be necessary for minus-end-directed motility. The ncd neck is found to differ from corresponding regions in the kinesin neck, conferring different symmetries of the distinct neck architectures.

Author: Vale, Ronald D., Sablin, Elena P., Fletterick, Robert J., Hart, Cynthia L., Case, Ryan B., Dai, Shirleko C., Ruby, Aaron
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Proteins

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How kinesin waits between steps

Article Abstract:

The development of two different single-molecule fluorescence resonance energy transfer (smFRET) sensor providing insight into hand-over-hand motion of kinesin-1 is reported. Kinesin is a dimeric motor protein that carrier cellular cargoes along microtubules mediated by transitions in the ATPase cycle.

Author: Vale, Ronald D., Mori, Teppei, Tomishige, Michio
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Science & research, Technology application, Fluorescence, Adenosine triphosphate, ATP, Hydrolysis, Chemical properties

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Subjects list: Research, Kinesin
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