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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses

Article Abstract:

Molecular cloning of the newly discovered interleukin-13 or IL-13 found in activated human T lymphocytes is discussed. Differential screening of an organized subtracted cDNA library from activated peripheral blood mononuclear cells was used to determine the function of IL-13. Results show the substance's role in inhibiting inflammatory cytokine production and in regulating interferon-gamma synthesis in large granular lymphocytes. Mapping also indicated that IL-13 is important in the regulation of inflammatory and immune responses.

Author: Minty, A., Chalon, P., Derocq, J.M., Dumont, X., Guillemot, J.C., Kaghad, M., labit, C., Leplatois, P., Liauzun, P., Miloux, B., Minty, C., Casellas, P., Loison, G., Lupker, J., Shire, D., Ferrara, P., Caput, D.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
Discovery and exploration, Interleukins, Lymphokines

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Therapeutic potentiation of the immune system by costimulatory Schiff-base-forming drugs

Article Abstract:

The formation of Schiff base is necessary in the induction of immune responses and a new costimulatory mechanism has been observed in CD4 Th- cells. Small molecules such as tucaresol that can form Schiff bases can act as substitutes for the physiological donor of carbonyl groups and can induce CD4 Th-cells by a mechanism that activates sodium and potassium ion transport. CD4 T lymphocytes induce immune responses.

Author: Rhodes, J., Chen, H., Hall, S. R., Beesley, J. E., Jenkins, D. C., Collins, P., Zheng, B.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
Physiological aspects, Schiff bases

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Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide

Article Abstract:

Inhibitory effects of calcitonin gene-related peptide (CGRP) on the antigen presentation of Langerhans cells (LC) indicate that this may be the link between the immune and nervous systems. CGRP has been found in the nerve fibers of the human epidermis and on the surface of sone LCs specially during inflammation. This results suggests the immunomodulatory function of CGRP in vivo.

Author: Hosoi, J., Murphy, G.F., Egan, C.F., Lerner, E.A., Grabbe, S., Asahina, A., Granstein, R.D.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
Research, Neuropeptides, Langerhans cells

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Subjects list: Immune response, Immune response regulation
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