Landmark stability is a prerequisite for spatial but not discrimination learning

Article Abstract:

A study of spatial learning in rats revealed that spatial understanding is only possible if the object remains in the same geometric frame of reference while discrimination is learned regardless of location. Rats were given a landmark to indicate good food and another for bad then the location of the landmark and food combination was changed. The rats were able to discriminate between the bad and good landmarks but were unable to locate the hidden food because the whole structure had been moved.

Discrimination learning

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Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1

Article Abstract:

The Thy-1 gene was inactivated in embryonic stem cells of mice. Regionally selective impairment of long-term potentiation (LTP) in the hippocampal formation was observed. However, use of the watermaze test showed that spatial learning by the Thy-1 deficient mice was not impaired. The results suggest that LTP in the cortical input to the dentate gyrus is not required for spatial learning.

Genetic aspects, Genetic regulation

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Glutamate-receptor-mediated encoding and retrieval of paired-associate learning

Article Abstract:

Animal model incorporates paired-associate learning to understand episodic memory in humans. Results reveal that rats encode two paired associates, food flavours and their spatial locations, and exhibit better-than-chance recall of one when cued by the other. Data indicate that this what-where paired associates are dependent on encoding and retrieval within hippocampus.

United Kingdom, Models, Evaluation, Physiological aspects, Influence, Cell receptors, Association of ideas, Association (Psychology), Learning in animals, Animal learning, Association tests

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