Yeast cell-type regulation of DNA repair

Article Abstract:

The mating-type locus (MAT) in the Saccharomyces cerevisiae yeast gives information on whether cells are of the mating type a, or alpha. Plasmid-rejoining assays have been performed and plasmids linearized by restriction enzymes were transformed into yeast. Transformant frequency was used to measure non-homologous end-joining (NHEJ). Experiments provide evidence against the direct role of heterochromatin formation in NHEJ, suggesting that its efficiency is controlled by cell type.

Observations, Gene expression, Saccharomyces

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Cripto-analysis of embryonic codes

Article Abstract:

In embryos of Drosophila the axis is dictated by molecular asymmetries generated during egg development, but in vertebrate embryos the axis is believed to results from influence of the organize region. Ding and colleagues have examined the function of Cripto, a gene belonging to a family that encodes secreted proteins with epidermal growth factor like motifs. Embryos lacking Cripto were found to have neither a streak nor an embryonic mesoderm.

Embryology, Animal embryology

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