An early pre-liver intra-embryonic source of CFU-S in the developing mouse

Article Abstract:

The spleen colony forming units (CFU-S) activity occurs in the aorta, gonad, mesonephros (AGM) region before the fetal liver where the CFU-S activity rate is greater than that in the embryonic yolk sac. The totipotent haematopoietic stem cells originate first during murine embryogenesis and then move to the fetal liver and lastly they colonize the bone marrow before birth. In vitro studies show that the yolk sac cells differentiate into various haematopoietic lineages.

Embryology, Animal embryology

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Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53

Article Abstract:

The retinoblastoma gene (RB) protein inhibits cell growth while c-myc promotes it. The two function with mutual antagonism, demonstrated by co-microinjection during G1 phase of the cell cycle. The presence of c-myc inhibits the RB protein from arresting the cell cycle, but does not interfere with the action of another tumor suppressor, p53.

Genetic aspects, Cell proliferation, Carcinogenesis, Retinoblastoma

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