Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein

Article Abstract:

A study of the lability of haem polymerase activity shows that polymerization is a chemical process mediated by haemozoin and beta-haematin. These results challenge the enzyme-mediation of the process and its dependence on protein. Chloroquine inhibits the activity of beta-haematin. Experimental studies reveal that both trophozoite lysate and acetonitrile extracts from synthetic beta-haematin support haem polymerization.

Physiological aspects, Parasites, Blood cells, Chloroquine

---

Aminoglycoside antibiotics induce bacterial biofilm formation

Article Abstract:

Demonstrations show that subinhibitory concentrations of aminoglycoside antibiotics induce biofilm formation in Pseudomonas aeruginosa and Escherichia coli. Results suggest that biofilm formation can be a specific, defensive reaction to the presence of antibiotics, and the molecular basis of this response includes alterations in the level of cyclic di-guanosine monophosphate.

United States, Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Bacteriostats, Antibacterial agents, Microbial mats

---

Similar abstracts:

• Abstracts: Selling out on nature. Field sports and conservation in the United Kingdom. Governance and the loss of biodiversity
• Abstracts: Global tests of biodiversity concordance and the importance of endemism. A test of the unified neutral theory of biodiversity
• Abstracts: Mating system and sex allocation in the gregarious parasitoid Cotesia glomerata. Polymorphic signals of harassed female odonates and the males that learn them support a novel frequency-dependent model
• Abstracts: Mid-infrared images of beta Pictoris and the possible role of planetesimal collisions in the central disk. How Mercury got its spin
• Abstracts: Low marine sulphate and protracted oxygenation of the Proterozoic biosphere

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.