Mechanical basis of meiotic metaphase arrest
Article Abstract:
The Drosophila melanogaster mei-9 and mei-218 genes are required in the late and early stages of the recombination pathway. Mutations in these genes result in the failure of chiasma formation. Microscopic analysis showed that these mutants also did not undergo normal metaphase arrest during meiosis.Since the two genes control different aspects of recombination, the results show that the failure of chiasma formation is the undelying cause of the lack of metaphase arrest. The results demonstrate that chromosomes are able to control the cell cycle.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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The millenium flies in
Article Abstract:
The first steps in the genetic analysis of the fly Drosophila melanogaster were taken almost one hundred years ago by W.E. Castle at Harvard University. The end of the 20th century sees the completion of the sequencing of the Drosophila genome. A new paper presents the 218 protein-coding genes in the 2.9-Mb of DNA encircling the alcohol dehydrogenase gene, of which 44% are represented in the existing collection of Drosophila expressed-sequence tags.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A meiotic gene conversion gradient opposite to the direction of transcription
Article Abstract:
Analysis of the HIS2 gene in Saccharomyces cerevisiae shows that polarity gradients necessary for meiotic recombination can be configured in more than one orientation in relation to the direction of genetic transcription. Moreover, these gradients are independent of the genetic promoter. Hence gene conversion and crossing-over do not necessarily entail initiation of recombination at fixed locations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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