Membrane-anchored aspartyl protease with Alzheimer's disease Beta-secretase activity
Article Abstract:
A new membrane-bound aspartyl protease (Asp2) with Beta-secretase activity, has been identified. It is widely expressed in brain and other tissues, and a decrease reduces amyloid Beta-peptide production and blocks accumulation of the carboxy-terminal APP fragments, created by Beta-secretase cleavage. Asp is thus a new protein target for drugs aimed at blocking the amyloid Beta-peptide and consequent formation of amyloid plaque in Alzheimer's disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease
Article Abstract:
The separation of corticotropin releasing factor (CRF) from its binding protein (BP) raises the free concentration of CRF in the Alzheimer's patients. A CRF-BP ligand fragments the CRF from the CRF-BP. The biologically active free CRF is essential for learning and memory in animals, and exhibits cognitive-enhancing effects in the brain of Alzheimer's patients. The CRF receptor agonists have no stress effects.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
Article Abstract:
Protein and RNA analyses of wild-type and homozygous mutant mice reveal that lung maturation in mice, having deficiency in corticotropin-releasing hormone, requires fetal glucocorticoid. The glucocorticoid deficiency exerts no influence on normal growth, fertility and longevity in postnatal mice. Glucocorticoid exerts significant influence on fetal rather than postnatal life.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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