A bad kinase makes good
Article Abstract:
Cell survival control is important in animal development and in diseases such as cancer. Phosphoinositide 3-kinase (P13K), along with its serine/threonine protein kinase AKt, have been implicated in a route conveying survival signals from cell-surface receptors. A missing piece in the pathway is the dissociation of Bad, a protein promoting cell death, from Bcl-xL, a cell survival factor. Akt has been identified as the kinase that phosphorylates Bad on the site needed for its interaction with 14-3-3.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Chemokines beyond inflammation
Article Abstract:
Chemokines were originally defined as host defence proteins, but also have other functions, with chemokine receptors such as CXCR4, important in the pathogenesis of HIV-1. Tachibana and colleagues and Zou and colleagues have reported that CXCR4 deletion is embryologically lethal in mice. This expands the biological significance of chemokines to a wider biological role than was first thought.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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