Membrane potential synchrony of simultaneously recorded striatal spiny neurons in vivo

Article Abstract:

The membrane potentials of all the neurons in a sample of 23 pairs of striatal neurons in rats anaesthetized with urethane and ketamine/xylazine showed clear 'up' and 'down' states. It was established that a large proportion of the state transitions of the striatal population are synchronized even over distances of a millimetre or more. There were some significant synchronous fluctuations in membrane potential within individual depolarized states, but action potentials were not synchronized. The fluctuations could represent activation of small groups of related cortical inputs embedded within the total cortical input signal.

Membrane potentials, Membrane potential

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How does xenon produce anaesthesia?

Article Abstract:

The molecular mechanism associated with the clinical activity of the anaesthetic gas xenon have remained poorly understood since its discovery. Most general anaesthetics heighten the activity of inhibitory GABA (gamma-aminobutyric acid type-A), but a new study shows that xenon has little effect on GABA, instead inhibiting the excitory NMDA (N-methyl-D-aspartate) receptor channels, which may partially explain some important features of its pharmacology, particularly its lack of undesirable side effects.

Physiological aspects, Observations, Xenon, Anesthesiology, Anesthetics

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