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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

Article Abstract:

The dynamic architecture of human Rad50/Mre11/Nbs1 (hR/M/N) is markedly affected by DNA binding. DNA binding by the hR/M/N globular domain leads to parallel orientation of the coiled coils and this prevents intracomplex interactions and favors intercomplex associations needed for DNA tethering.

Author: Dekker, Cees, Kanaar, Roland, Dekker, Nynke H., Moreno-Herrero, Fernando, de Jager, Martijin, Wyman, Claire
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
DNA repair, Conformational analysis

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Antitumour drugs impede DNA uncoiling by topoisomearse 1

Article Abstract:

A single molecule nanomanipulation is used to monitor the dynamics of human topoisomerase I in the presence of topotecan, which enabled the detection of binding an unbinding of individual topotecan molecule in real time and to quantify the drug-induced trapping of topoisomerase in DNA.

Author: Koster, Daniel A., Dekker, Nynke H., Palle, Komaraiah, Bot, Elisa S.M., Bjomsti, Mary-Ann
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
DNA topoisomerase I, Antineoplastic antibiotics

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Electron-hole symmetry in a semiconducting carbon nanotube quantum dot

Article Abstract:

The measurements of the discrete, quantized-energy spectrum of electrons and holes in a semiconducting carbon nanotube are reported. The discrete excitation spectrum for a nanotube with N holes is strikingly similar to the corresponding spectrum for N electrons.

Author: Dekker, Cees, Kouwenhoven, Leo P., Jarillo-Herrero, Pablo, Sapmaz, Sami, Zant, Herre S. J. van der
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Semiconductors, Electron-electron interactions, Semiconductors (Materials)

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Subjects list: Research, United States, DNA-ligand interactions, DNA binding
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