Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

Article Abstract:

Serum paraoxonase (PON1) is an esterase linked with high-density lipoproteins (HDLs) in plasma, involved in detoxification of organophosphate insecticides. The role of PON1 was studied in vivo, with the creation of PON1-knockout mice by gene targeting. PON1-deficient mice were sensitive to chlorpyrifos oxon toxicity, and HDLs isolated from them could not prevent low-density lipoprotein oxidation. PON1-null mice became more susceptible to atherosclerosis when fed on a high fat, high cholesterol diet, than wild type littermates.

Atherosclerosis, Organophosphorus compounds, Organic phosphorus compounds, Toxicity testing, Toxicity tests

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Out from the haze

Article Abstract:

The controversies arising from the ban on smoking in enclosed public places and the link between second hand smoke and heart disease is explained.

United States, Science & research, Health aspects, Causes of, Heart diseases, Passive smoking, Public health law, Smoking bans

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