Mitotic chromatin regulates phosphorylation of Stathmin/Op18

Article Abstract:

The even segregation of duplicated chromosomes in daughter cells requires meiotic and meiotic spindles, whose mechanism is unclear. It has been shown, in vitro, that Stathmin/Op18 is involved in the inhibition of microtubule polymerization by interacting with tubulin and that the assembly of mitotic spindles is prevented by overexpression of non-phosphorylatable mutants of Stathmin/Op18. A new study, using Xenopus egg extracts and magnetic chromatin beads, shows that phosphorylation of Stathmin/Op18 is regulated by mitotic chromatin.

Chromatin, Proteins, Cell cycle, Spindle (Cell division), Spindle (Cytoplasm)

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Dynamics and mechanics of the microtubule plus end

Article Abstract:

Analysis of the functions of microtubules in the movement of cellular organelles is explored. The article identifies three properties of microtubule ends that form a type of molecular 'machine' which aids the process: alternate structures, biochemical transition, and the ability to form distinct binding targets for certain proteins.

Research and Development in the Physical, Engineering, and Life Sciences, Cellular Biology, Cytology, Properties

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Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos

Article Abstract:

Polarity establishment requires a symmetry-breaking event, resulting in an axis along which determinants are segregated. The contribution of the centrosome to polarity establishment by laser ablating the centrosome before and during polarization is assessed.

Measurement, Polarization (Electricity), Centrosomes, Centrosome, Embryo

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