Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

Article Abstract:

DNA fragment cloning and Southern blot analysis was used to discover a Bcl-2 homologue that is responsible for cell death in the myocardium after reperfusion and ischaemia. The bak gene product was discovered that has similarities to Bax in that both require a specific stimulus to accelerate apoptotic cell death. However, Bak's apoptosis-stimulating process appears to be widespread based on the widely distributed Bak messenger RNA enabling Bak to suppress cell death in an Epstein-Barr-virus-transformed cell line unlike Bax. The mechanism may involve interactions with anti-apoptotic viral proteins.

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The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis

Article Abstract:

A new protein binding to caspase-8, FLASH, has been identified. It is shown to contain a motif related to CED-4/Apaf-1 and two tandem-repeated DED homologous domains, required for caspase-8 activation during Fas-mediated apoptosis. Transient expression of FLASH activates caspase-8, and overexpression of full-length FLASH prevents the anti-apoptotic effect of the adenovirus protein E1B19K.

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Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast

Article Abstract:

The protein Ash1 mRNA is shown to be localized to the distal tip of daughter buds in post-anaphase cells. Ash1 mRNA's particles associate with the cell cortex, but it is not localized correctly when a myosin is mislocalized to the mother-bud neck. It is proposed that saccharomyces cerevisiae uses RNA localization to distribute proteins and determine cell fate.

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