Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Article Abstract:

Crystallographic analyses of the virally hijacked form of the human DDB1-CUL4A-ROC1 machinery is presented which show that DDB1 uses one [beta]-propeller domain for cullin scaffold binding and a variably attached separate double-[beta]-propeller fold for substrate presentation. It reveals the structural mechanisms and molecular logic underlying the assembly and versatility of a new family of cullin-RING E3 complexes.

Canada, Analysis, Genetic aspects, Crystallography, Ligases, Mutagenesis, Ubiquitin-proteasome system

---

Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway

Article Abstract:

Inappropriate activation of downstream target genes by the oncoprotein beta-catenin is implicated in development of numerous human cancers. Inhibition of Drosophila Chibby by RNA interference results in segment polarity defects that mimick a wingless gain-of function pheno-type and overexpression of the wingless target genes engrailed and Ultrabithorax

RNA, Drosophila, Genes

---

Surface mechanics mediate pattern formation in the developing retina

Article Abstract:

E- and N-cadherins mediate apical adhesion between cells in the epithelium. The results demonstrate how the simple expression pattern of two adhesion proteins could render a complex pattern of cells in a developing biological structure.

United States, Retina, Cell adhesion, Structure

Similar abstracts:

• Abstracts: Molecular structure in an instant. Seeing the light. Negative refraction by photonic crystals
• Abstracts: Molecular hydrogen beyond the optical edge of an isolated spiral galaxy. Universal alignment of hydrogen levels in semiconductors, insulators and solutions
• Abstracts: Mate attractiveness and primary resource allocation in the zebra finch
• Abstracts: Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. The genome sequence of the rice blast fungus Magnoporthe grisea
• Abstracts: Long-term eruptive activity at a submarine arc volcano. An off-axis hydrothermal vent field near the Mid-atlantic ridge at 30 degrees N

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.