Molecular basis of sun-induced premature skin ageing and retinoid antagonism

Article Abstract:

Long-term exposure to sunlight results in skin collagen and elastin damages that are believed to be the cause of wrinkles. It is shown that mere hours of exposure to solar ultraviolet irradiation can stimulate collagen- and elastin-damaging metalloproteinase messenger RNAs, proteins and activities in the human skin in vivo. If the resulting degradation of the extracellular matrix is not properly repaired, it will create solar scars that may eventually cause the skin to age prematurely.

Aging, Analysis, Environmental aspects, Skin, Radiation effects, Skin, Effect of radiation on the, Skin Aging

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Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy

Article Abstract:

The strength spectra for bonds between streptavidin and biotin is reported. Bond formation was probed over six orders of magnitude and it was found that bond survival time time was reduced. Bond strength was found to increase however. This indicates that the bonds appear strong or weak depending on how rapidly they are loaded. Activation barriers from the strength spectra were related to the shaped of the energy landscape from biotin-avidin complex simulations.

Usage, Molecular dynamics, Atomic force microscopy

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Structural basis of HutP-mediated anti-termination and roles of the Mg(super 2+) ion and L-histidine ligand

Article Abstract:

The 1.60-angstrom resolution crystal structure of the quaternary complex [HutP-L-histidine-Mg(super 2+)-21-base single-stranded RNA] is reported. The structure explains how the HutP and RNA are regulated critically by the L-histidine and Mg(super 2+) ion through the structural rearrangement.

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