Imprinting and splicing join together

Article Abstract:

Three papers published in the Dec 1992 issue of Nature Genetics reveal new findings about the genetic origin of Prader-Willi syndrome (PWS). PWS, which results from either the lack of a paternal gene or from having two copies of the maternal chromosome 15, causes obesity and developmental problems. Stuart Leff and colleagues report the association of the gene SNRPN with PWS, while Neal Copeland and Nancy Jenkins achieved a similar result. Bruce Cattanach and coworkers corroborated this finding by devising a mouse model of PWS.

Genetic aspects, Prader-Willi syndrome

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Of mice and men (and cows and cats)

Article Abstract:

A listing exists of 321 mapped locations of human genes with homologues for the cat, mouse and cow. The genes have been cloned and their locations on the chromosomes are given, providing a foundation for any further mapping studies. Stephen O'Brien and colleagues have produced the master map, and it will facilitate cross species studies since it represents mammalian orders of carnivores, primates, rodents and artiodactyls.

Research, Chromosome mapping

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