Multiple molecular mechanisms for multidrug resistance transporters

Article Abstract:

Various structural and biochemical data are obtained to gain insight into the working and properties of several multidrug resistance transporters that pump a broad spectrum of cytotoxic molecules out of cells, considering antibiotics and herbicides in humans. The analysis shows that the acquisition of multidrug resistance is a big hindrance to the development of healthcare and hence new methods need to be developed to achieve multispecifity for different drugs.

Analysis, Molecular dynamics, Drug resistance

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Atomic structures of amyloid cross-[beta] spines reveal varied steric zippers

Article Abstract:

The segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both, which include segments from Alzheimer's amyloid-[beta] and tau proteins, are described. The structures of these microcrystals have revealed steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.

Prions, Prions (Proteins), Crystals, Crystal structure

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Structure of the cross-beta spine of amyloid-like fibrils

Article Abstract:

The atomic structure of the cross-beta spine is determined from a seven-residue segment from Sup35 forms amyloid-like fibrils and closely related microcrystals. The structure illuminates the stability of amyloid fibrils, their self-seeding characteristic and their tendency form polymorphic structures.

United States, Polymorphism (Crystallography)

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