Mutant mice live longer
Article Abstract:
Mice with a single targeted mutation in the gene encoding the p66shc protein appear to live almost one-third longer than wild-type animals. This research supports the hypothesis that oxidative damage can have a substantial impact on lifespan, without apparent damaging side effects. It was established that cells derived from mice with mutant p66shc are more resistant than those from wild-type animals to agents that produce oxidative damage, but not to X-rays, believed to damage DNA in a non-oxidative manner.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Correct Hox gene expression established independently of position in Caenorhabditis elegans
Article Abstract:
Correct Hox gene expression in Caenorhabditis elegans is regulated by a cell lineage-specific control system. This expression is independent of the cell position. Mechanisms other than cell-extrinsic A/P positional signals are essential for gene expression regulation. However, in some cells, A/P positional information mediates Hox gene expression, or acts along with other mechanisms to enable highly reproducible gene expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Genetic pathways that regulate ageing in model organisms
Article Abstract:
Research into the genetic influences on the ageing process is discussed. Particular focus is given to studies of the genetic pathways which regulate ageing in model organisms including mice and fruitflies.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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- Abstracts: Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
- Abstracts: A Hox by any other name. Hox genes and the making of sphincters. Hox gene expression in teleost fins and the origin of vertebrate digits
- Abstracts: Push and pull of base flipping. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity
- Abstracts: Alternative feeding strategies and potential disease transmission in Wisconsin white-tailed deer. Sex affects age determination and wear of molariform teeth in white-tailed deer
- Abstracts: Group size and aggression: 'recruitment incentives' in a cooperatively breeding primate. Variation in steroid hormones associated with infant care behaviour and experience in male marmosets (Callithrix kuhlii)