Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Article Abstract:

The ADP-ribosyltransferase activity of yeast Sir2, a heterochromatin element that silences transcription at silent mating loci, telomeres and the ribosomal DNA, may play a role in DNA repair. This hypothesis is supported by research indicating that the ADP-ribosylation of histones takes place when cells are treated with DNA damaging agents and that antibodies against mono-ADP-ribose react with mammalian nuclei only when cells are treated with DNA-damaging agents. The nicotinamide adenine dinucleotide requirement of Sir2 for deacetylation indicates that this protein could be a sensor of the energy or oxidation state of cells.

Research, Genetic regulation, Genetic transcription, Transcription (Genetics), Genetic recombination

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Sirtuins as potential targets for metabolic syndrome

Article Abstract:

The research in the field of ageing, which might help to identify important mediators of calorie restriction offering the hope of new drugs to improve healthspan is explored. Findings reveal that sirtuins and other important metabolic pathways that affect calorie restriction might serve as entry points for drugs to treat ageing, insulin insensitivity, obesity and other symptoms associated with metabolic syndrome.

United States, Health aspects, Care and treatment, Causes of, Risk factors, Obesity, Enzymes, Diet therapy, Enzyme therapy, Metabolic syndrome X

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Article Abstract:

Research is presented concerning the mutations of Caenorhabditis elegans which reduce the effectiveness of an insulin-like receptor and extend the lifespan of the adults. The influence of the sir-2 gene is discussed.

Genetic aspects, Caenorhabditis elegans, Letter to the Editor, Longevity

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