NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

Article Abstract:

Activation of the nuclear transcription factor NF-kappaB requires a signalling pathway leading to phosphorylation of IKK-alpha by Akt (protein kinase B). This research indicates that Akt serine-threonine kinase is involved in the activation of NF-kappaB by tumour necrosis factor. It has been possible to identify a mechanism through which Akt could suppress apoptosis. It is suggested that Akt could play a role in cytokine-mediated immunity.

---

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

Article Abstract:

Ca(super2)+/calmodulin-dependent protein kinase kinase (CaM-KK) is shown to activate protein kinase B (PKB) directly, leading to phosphorylation of BAD. A three to fourfold rise in cell death of NG108 neuroblastoma cells was induced by serum withdrawal, and the apoptosis was mostly blocked by raising the intracellular Ca(super2+) concentrations with NMDA. This suggests a Ca(super2)+-triggered signalling cascade.

Calmodulin

---

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

Article Abstract:

Research is presented concerning the role of glycogen synthase kinase-3-alpha and -beta in the inhibition of Wnt signalling during adult tissue cell proliferation and embryonic development.

Liver, Glycogen, Embryology, Animal embryology, Letter to the Editor

Similar abstracts:

• Abstracts: Role of Rel/NF-kappa-B transcription factors during the outgrowth of the vertebrate limb. Transcriptional activation by BRCA1
• Abstracts: Glycine-receptor activation is required for receptor clustering in spinal neurons. SNAP-mediated protein-protein interactions essential for neurotransmitter release
• Abstracts: EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
• Abstracts: Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. Nuclear pore complexes in the organization of silent telomeric chromatin
• Abstracts: Osmotic generation of 'anomalous' fluid pressures in geological environments. Mechanosensitive channels transduce osmosensitivity in supraoptic neurons

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.