Negative regulation of T-cell adhesion and activation by CD43
Article Abstract:
T-lymphocytes isolated from CD43-deficient mice exhibit enhanced sensitivity to antigens. The increased activation is probably because of increased ability of the T-cells to adhere on homotypes and to bind ligands. The suppression of adhesion by CD43 is either due to direct inhibition or its net negative surface charge. CD43-deficient T-cells proliferate more in the presence of anti-CD43, superantigen SEB or allostimulation than the normal T-cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
Article Abstract:
Research shows that T cell are activated (imprinted) toward gut sites by dendritic cells from Peyer's patches. Data indicate that although other cells can activate T cells, only Peyer's patch dendritic cells can induce gut-homing specificity on T cells at high levels.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Transvascular delivery of small interfering RNA to the central nervous system
Article Abstract:
The study results related to a short peptide derived from rabies virus glycoprotein (RVG) which enables the transvascular delivary of small interfering RNA (siRNA) to the brain is reported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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