Neuronal position in the developing brain is regulated by mouse disabled-1
Article Abstract:
Neuronal layering in the cerebral cortex, hippocampus and cerebellum is disturbed by targeted disruption of the mouse disabled1 (mdab1) gene. A cytoplasmic protein, mDab1 p80, is encoded by this gene. The protein is expressed and tyrosine-phosphorylated in the developing nervous system. It has no known catalytic activity, so may act as a docking protein to link proteins together through its amino-terminal PI/PTB domain and tyrosine-phosphorylated motifs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Beating a path to Myc
Article Abstract:
Researchers report on a new pathway to the c-myc gene that allows growth factors to regulate gene expression. C-myc encodes the Myc transcription factor. The pathway uses the non-receptor tyrosine kinase Src and bypasses Ras. The new pathway is similar to the Ras pathway. Both the pathways are stimulated by the platelet-derived growth factor receptor, and both are involved in the process that culminates in DNA synthesis and cell division.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Molecular switches in lipid rafts
Article Abstract:
New research into signal transduction is presented which identifies what could be a key regulator of the SFKs (the Src-family kinases).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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