Nicotine activates and desensitizes midbrain dopamine neurons
Article Abstract:
Research demonstrates that nicotine activates and desensitizes multiple nicotine receptors in the animal midbrain. Evidence from experiments using ventral tegmental area neurons of the mesolimbic dopamine system in rats suggests that while nicotine stimulates dopamine neurone activity, it causes nicotinic receptor desensitization shortly afterwards. Thus, nicotine tolerance seems to numb the pleasurable effects of smoking.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Disease threat to European fish
Article Abstract:
A demonstration that the holding water of Pseudorasbora parva acted as an absolute inhibitor of spawning for Leucaspius delineatus and caused a large increase in fish mortality is presented. The results suggest that an infectious organism caused the decline in Leucaspius delineatus from sharing water with Pseudorasbora parva.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Nanofabrication of solid-state Fresnel lenses for electron optics. X-ray lenses near reality
- Abstracts: Reduction in hunting success and settlement strategies in young Spaish imperial eagles. Philopatry or dispersal: competition for territory vacancies in the splendidfairy-wren, Malurus splendens
- Abstracts: Optical detection of magnetic resonance in a single molecule
- Abstracts: NIDCD research on taste and smell. A specific amyloid-beta protein assembly in the brain impairs memory. Aluminum - Alzheimer's link?
- Abstracts: Using antibodies to perturb the coordination sphere of a transition metal complex. Characterization of a functionally important mobile domain of GroES