Non-transcriptional control of DNA replication by c-Myc

Article Abstract:

The c-Myc proto-oncogene has a direct role in the control of DNA replication and it has interacted with the pre-replicative complex and localized to early sites of DNA synthesis. The studies have shown the important function of c-Myc in DNA replication and have suggested a novel mechanism for its normal and oncogenic functions.

Oncogenes

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Origins of licensing control

Article Abstract:

The mechanism involved in fertilization to maturity of cells is known as replication licensing. The process of replicating licensing involves the sequential assembly of components of a replication complex onto the regions from which DNA replication begins.

Organogenesis

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Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

Article Abstract:

A study of the function of single E1enzymes in the activation and conjugation of ubiquitin revealed dual activation of E1to regulate E2 charging.

Analysis, Gene mutations, Gene mutation, Genetic aspects, Ubiquitin, Structure, DNA microarrays

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