One-stop shop for microarray data: is a universal, public DNA-microarray database a realistic goal?
Article Abstract:
A rough draft of the entire human genome should be available by spring 2000, but scientists are still a long way from a clear understanding of gene function. Obtaining information about gene expression is a much greater challenge than DNA sequencing, as gene expression is a dynamic process influenced by many factors. DNA microarray and 'chip' technologies make it possible to investigate gene expression in an organism on a genomic scale, permitting the transcription levels of many genes to be measured at the same time. It is now time to form a public repository for microarray data, with standardized annotation. However, this is a difficult task, and will present bioinformatics with a significant challenge.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Molecular switches in metastasis
Article Abstract:
Research on the genes which can cause metastasis, the spread of cancerous cells, is discussed. Scientists used gene-expression profiling to identify which genes are responsible for the molecular changes leading to metastasis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Single-molecule analysis of DNA uncoiling by a type II topoisomerase
Article Abstract:
It is possible to observe the action of a single topo II as it uncoils a DNA molecule directly and in real time. It is clear that single molecule experiments are a strong new tool for the study of topoisomerases.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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