Osteoclast differentiation and activation

Article Abstract:

This review discusses osteoclastogenesis and bone resorption in terms of the role played by osteoclasts. Research shows that the monocyte/macrophage haematopoietic lineage derived osteoclasts adhere to bone matrix and degrade it in extracellular compartments. The receptor activator of nuclear factor (RANK) signalling pathway in the osteoclasts mediates hormonal signals influencing bone mass and structure.

Science & research, Research, Bone density, Bone resorption, Bone cells, Company growth, Structure

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HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

Article Abstract:

Research demonstrates that macrophages, containing the viral replication Nef protein, upon stimulation by CD40 receptor release a paracrine factor that converts T lymphocytes susceptible for HIV-1 infection bypassing cell cycle. Data indicate two soluble proteins, CD23 and ICAM are induced from macrophages by Nef and CD40L.

HIV infection, HIV infections, T cells, Disease susceptibility

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Developmental regulation of the growth plate

Article Abstract:

This review discusses endochondral bone formation with respect to the formation of skeleton. Research reveals that the process involves signalling pathways and transcription factors, which control and regulate bone growth plate at the cellular level.

Analysis, Influence, Genetic aspects, Genetic transcription, Transcription (Genetics), Morphogenesis

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