Expression of the transcription factor delta-FosB in the brain controls sensitivity to cocaine

Article Abstract:

It has been established that selective induction of delta-FosB in dynorphin/substance-P-containing neurons of the NAc and dorsal striatum in the adult is sufficient to boost an animal's responsiveness to the rewarding and locomotor-activating effects of cocaine. It is possible that induction of delta-FosB by chronic cocaine exposure is a mechanism for quite long-lasting rises in sensitivity to the stimulant and rewarding effects of the drug. This research also showed that increased GluR2 expression in the NAc can explain the enhanced sensitivity to cocaine's rewarding effects noted in the delta-FosB-expressing mice.

Physiological aspects, Drug abuse, Cocaine

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Cocaine abuse takes a shot

Article Abstract:

Active immunization against cocaine may be an effective method for treating cocaine addicts. Stable conjugates similar to drugs are linked to a foreign carrier protein which stimulates the immune system to generate antibodies. The antibodies then neutralize the cocaine and prevent its passage to the brain. Thus, the psychoactive effects do not take place. However, immunization has the potential danger of developing allergic reaction in the patient in varying degrees from mild to severe, which may cause death.

Health aspects, Care and treatment, Drug therapy, Drug addicts, Drug abusers, Cocaine abuse, Immunization

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Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour

Article Abstract:

A brain region involved in cocaine addiction shows biochemical changes in response to 'extinction training', a form of inhibitory learning, according to researchers at several centers in the US. Specifically, there were increases in the GluR1 and GluR2/3 subunits of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate) glutamate receptors in the nucleus accumbens shell.

United States, Science & research, Research, Neurology, Addiction

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