Peptides bound to MHC

Article Abstract:

The lack of supporting data undermines the contention that approximately six different peptides make up most major histocompatibility complex (MHC) class II molecules. This conclusion, which resulted from relying too much on the analysis of only a few MHC-bound peptides, is nonquantitative. However, a case can be made that the data do indicate the complexity of self peptides, especially when the analysis involves finding out the peptide:MHC density requirements.

Peptides, Major histocompatibility complex

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Article Abstract:

The cloning and characterization of a human homologue of the Drosophila toll protein is reported. The human toll protein is a type I transmembrane protein with a leucine-rich repeat domain and a cytoplasmic domain. Drosophila toll and the human interleukin receptor can both signal through the NF-kappaB pathway, and the study shows the activation of NF-kappaB is induced by a constitutively active mutant of human toll, transfected into human cell lines.

Psychological aspects, Physiological aspects, Proteins, Immunity, Immunity (Physiology), Drosophila

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