Pituitary hormone FSH directs the CREM functional switch during spermatogenesis
Article Abstract:
The developmental switch that occurs in the cyclic AMP-responsive element modulator during spermatogenesis was investigated. The extinction of CREM tau expression in testis was observed in hypophysectimized rats and the role of the pituitary-hypothalamic axis was shown. Through seasonal-dependent modulation of spermatogenesis and administering pituitary-derived hormones, the role of the follicle stimulating hormone in the switch was confirmed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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CPB-independent activation of CREM and CREB by the LIM-only protein ACT
Article Abstract:
CREB and CREM transcriptional activation needs serine residue phosphorylation in the activation domain 133 in CREB. CREM is highly expressed in male germ cells and is needed for post-meiotic gene expression. A testis-derived complementary DNA encoding the ACT protein has been isolated. This expressed with CREM in a tissue and developmentally regulated way, stimulating CREM transcriptional activity in yeast and mammalian cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Severe impairment of spermatogenesis in mice lacking the CREM gene
Article Abstract:
The cyclic adenosine monophosphate-responsive element modulator (CREM) gene is vital in spermatogenesis. Mice deficient for the CREM gene may be used as a model for the study of idiopathic infertility in men, specifically in formulating a strategy to regulate male fertility. This was gleaned from the selective elimination of the transcription factor REM using gene targeting to determine its biological significance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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