Plastid in human parasites

Article Abstract:

High-resolution in situ hybridization techniques reveals the presence of a plastid in human malarial and toxoplasmodial parasite cells. The plastid like parasite genes is located on a 35-kilobase DNA circle. Transcripts of the 16S ribosomal RNA gene from Toxoplasma gondii are small and have ovoid organelles with a layer of endoplasmic reticulum. The Plasmodium falciparum parasite organelle appears similar to the T. gondii plasmid. The presence of plastid opens up possibilities for the production of parasite-specific therapeutic agents.

Methods, Analysis, In situ hybridization, Plastids, Toxoplasma

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A protective paradox

Article Abstract:

The P.yoelii circumsporozoite (PyCSP_-tolerant mice with attenuated P. yoelii sporozoites were immunized to determine whether animals that could not respond to PyCSP could still produce protective immunity against the malaria parasite. The results reveal that PyCSP is responsible for 90% of the protection and is thus immunodominant that is the majority of the protective cellular and antibody responses are directed against this protein rather than against other proteins.

Science & research, Protein research, Sporozoa

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Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells

Article Abstract:

Plasmodium falciparum, the malaria parasite, is a successful human pathogen, and specific immunity to malaria is attributed to the occurrence of cytotoxic lymphocytes or antibodies. It is shown that intact malaria-infected erythrocytes bind to dendritic cells and inhibit their maturation, reducing their ability to stimulate T cells.

Malaria, Antigen presenting cells

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