Polarity-specific activities of retinoic acid receptors determined by a co-repressor
Article Abstract:
The binding of retinoic acid receptors (RAR) and retinoid-X receptors (RXR) as heterodimers to cognate DNA sites, oriented as direct repeats of a core binding motif, occurs in a polarity-specific manner. The destabilization of a novel nuclear receptor co-repressor, N-Co-R, and the employment of putative co-activators causes the differential response of RAR to activating ligands on DR + 5 elements. DNA-response elements allosterically mediate RAR-co-repressor activity to regulate gene expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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New wrinkles in retinoids
Article Abstract:
Mitinori Saitou of Kyoto University, faculty of medicine, has discovered the process which is associated with the influence of retinoids in the development of an organ. Saitou used a targeted expression of a dominant negative retinoic acid receptor (RAR) in transgenic mice for investigating the influence of retinoids. His investigation reveals that the retinoids need not necessarily inhibit epidermal differentiation but enhance the regular retinoid maturation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
Article Abstract:
Allosteric inhibition of retinoid-X receptor (RXR) is shown to be due to a rotation of the RXR AF-2 helix that puts it in contact with the retinoic-acid receptor (RAR) coactivator binding site. An LXXLL motif of SRC-1 to RAR displaces the RXR AF-2 domain, enabling RXR ligands to bind and promote binding. The results could explain the differing responses of nuclear-receptor heterodimers to RXR-specific ligands.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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