Potentiation of cortical inhibition by visual deprivation

Article Abstract:

A demonstration that visual deprivation leaves excitatory connections in layer 4 (the primary input layer to cortex) unaffected, but markedly potentiates inhibitory feedback between fast-spiking basket cells (FS cells) and star pyramidal neurons (star pyramids) is presented. The analysis data has suggested that potentiation of inhibition is a major cellular mechanism underlying the deprivation-induced degradation of visual function, and that this form of long-term potentiation of inhibition (LTPi) is important in fine-tuning cortical circuitry in response to visual experience.

Vision research, Synapses, Synaptic vesicles

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Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex

Article Abstract:

Transcriptional two-photon microscopy is used to visualize postsynaptic dendritic spines in layer I of the barrel cortex in transgenic mice expressing yellow fluorescent protein. A demonstration that in young adolescent mice, long-term sensory deprivation through whisker trimming prevents net spine loss by preferentially reducing the rate of ongoing spine elimination, not by increasing the rate of spine formation is prevented.

Influence, Sensory deprivation, Dendritic cells

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Activity-dependent scaling of quantal amplitude in neocortical neurons

Article Abstract:

A new type of synaptic plasticity that increases or decreases the strength of all of a neuron's synaptic inputs, is described. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) were increased with chronic blockade of cortical culture activity. Changes were partly due to postsynaptic alterations in response to glutamate, affecting each synapse in proportion to initial strength.

Neural transmission, Synaptic transmission

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