BRAF mutation predicts sensitivity to MEK inhibition

Article Abstract:

The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK) and extracellular signal regulated kinase (ERK) is activated in most human tumours and it is seen that mutation of BRAF is associated with enhanced and selective sensitivity to MEK inhibition. The data suggests an exquisite dependency on MEK activity in BRAF mutant tumours, and offer a rational therapeutic strategy for this genetically defined tumour subtype.

Gene mutations, Gene mutation, Cancer genetics

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

Article Abstract:

The melanocyte master regulator MITF (micro phthalmia-associated transcription factor) as a target of a novel melanoma amplification by integrating single-nucleotide polymorphism (SNP) array based genetic maps with gene expression signatures derived from NC160 cell lines are identified. The findings state that MITF amplification is more prevalent in metastatic disease and correlated with decreased overall patient survival.

Genetic aspects, Genetic transcription, Transcription (Genetics), Genetic polymorphisms, Melanocytes

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MicroRNA expression profiles classify human cancers

Article Abstract:

A systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers is presented using a new, bead-based flow cytometric miRNA expression profiling method. The miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of tumors.

Development and progression, Gene expression, RNA

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