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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Article Abstract:

An analysis of a panel of human lung hyperplasias is done, which shows that all of them retain wild-type p53 genes and had no signs of gross chromosomal instability and also found signs of a DNA damage response. It is proposed that cancer development is associated with DNA replication stress, which leads to DNA double-strand breaks, genomic instability and selective pressure for p53 mutations.

Author: Halazonetis, Thanos D., Zacharatos, Panayotis, Gorgoulis, Vassilis G., Vasiliou, Leandros-Vassilios F., Karakaidos, Panagiotis, Kotsinas, Athanassios, Liloglou, Triantafillos, Venere, Monica, DiTullie,Richard A., Jr., Kastrinakis, Nikolaos G., Levy, Brynn, Kletsas, Dimitris, Yoneta, Akihira, Herlyn, Meenhard, Kittas, Christos
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Genetic disorders

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

Article Abstract:

The structure of the domain of the protein 53BP1 that recruits it to sites of double-strand breaks (DSBs) is solved. This domain consists of two tandem tudor folds with a deep pocket at their interface formed by residues conserved in the budding yeast Rad9 and fission yeast Rhp9/Crb2 orthologues.

Author: Huyen, Yentram, Ditullio, Richard A., Jr., Zacharatos, Panayotis, Sheston, Emily A., Zgheib, Omar, Gorgoulis, Vassili, Petty, Tom J., Mellert, Hestia S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
United States, Eukaryotes, Methylation, Lysine

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Resistance to therapy caused by intragenic deletion in BRCA2

Article Abstract:

The significance of the intragenic deletion of a BRCA2 mutation in the development of resistance against the poly(ADP-ribose) polymerase (PARP) is analyzed. Cells with loss of the BRCA2 function are found to be highly sensitive to the PARP inhibitors.

Author: Boyd, Jeff, Ashworth, Alan, Lord, Christopher J., Levine, Douglas A., Edwards, Stacey L., Brough, Rachel, Natrajan, Rachael, Vatcheva, Radost, Reis-Filho, Jorge S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
Genetic recombination

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Subjects list: Research, Gene mutations, Gene mutation, DNA damage
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