Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation

Article Abstract:

The activation of the phosphatase Cdc14 at anaphase onset is both necessary and sufficient for silencing microtubule dynamics in the budding yeast 'Saccharomyces cerevisiae'. It has been noticed that Cdc14 promotes localization of microtubule-stabilizing proteins to the anaphase spindle, and dephosphorylation of the kinetochore component Ask1 contributes to both the silencing of microtubule turnover and successful anaphase A.

Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Protein kinases, Phosphatases, Brewer's yeast, Saccharomyces cerevisiae

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Separase-mediated cleavage of cohesin at interphase is required for DNA repair

Article Abstract:

A study was conducted for showing that securin was essential for separase stability and for proper repair of DNA that were damaged due to ultraviolet, X-ray and (gamma)-ray irradiation. The results suggest that the DNA repair might be assisted by the securin-separase complex through the removal of local cohesion in interphase cells.

DNA repair, Cell adhesion

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