Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen processing

Article Abstract:

Proteasome subunits encoded by major histocompatibility complex (MHC) are not essential for the stable surface expression of MHC class I molecules. Nor are they required for the presentation of antigenic peptides to the cell surface from influenza virus and from an endogenously synthesized intracellular protein. This is discovered by furnishing a human cell line lacking both transporter and proteasome subunit genes with genes from a rat that encode the MHC-linked transporters.

Genetic aspects, Major histocompatibility complex, Antigen presenting cells

---

Disulphide-isomerase-enabled shedding of tumor-associated NKG2D ligands

Article Abstract:

The soluble major histocompatibility complex class-I-related ligand MICA is associated with endoplasmic reticulum protein 5 (ERp5) on the surface of the tumour cells, which has assisted in the folding of nascent proteins inside cells. The results have revealed a molecular mechanism where the domain-specific deconstruction has regulated MICA protein shedding, promoting tumour immune evasion and identifying surface ERp5 as a strategic target for therapeutic intervention.

Science & research, Research, Physiological aspects, Endoplasmic reticulum, Tumors, Protein research, Tumours

---

Similar abstracts:

• Abstracts: Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Playing upon both sides
• Abstracts: How to publish the unpalatable? Polite row about models in biology. Systematic errors in 'Big G'?
• Abstracts: Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
• Abstracts: Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission. A retrograde step forward
• Abstracts: Modelling the hydrological cycle in assessments of climate change

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.