Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins

Article Abstract:

An unexpected role for protein kinase A (PKA) signalling via CREB is described. Using a combination of in vitro explant assays, mutant analysis and gene delivery into mouse embryos cultured ex vivo, it is demonstrated that adenylyl cyclase signalling via PKA and its target transcription factor CREB are required for Wnt-directed myogenic gene expression.

United States, Glycoproteins, Myogenesis

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Hedgehog signaling activity of smoothened requires phosphorylation by protein kinase A and casein kinase I

Article Abstract:

Protein kinase A (PKA) and casein kinase I (CKI) regulate Smo cell-surface accumulation and activity in response to Hh. It is stated that PKA and CKI phosphorylate Smo at several sites, and that phosphorylation-deficient forms of Smo fail to accumulate on the cell surface and are unable transduce the Hh signal.

Dry, Condensed, and Evaporated Dairy Product Manufacturing, Dry, condensed, evaporated products, Casein, Hedgehogs

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Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

Article Abstract:

The impact of genetically modified macrophage migration inhibitory factor (MIF) expression on the response of the human heart to ischaemia by the AMP-activated protein kinase (AMPK) is described. The findings from the diagnostic MIF genotyping would help to predict risk in patients with coronary artery disease.

Physiological aspects, Macrophage colony stimulating factor

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