RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits
Article Abstract:
The regulator of G-protein signalling (RGS) in the signal transduction pathway, are GTPase activating proteins (GAPs) for G-alpha subunit. The deactivation of the G-protein signalling occurs faster than the rate of GTP hydrolysis of G-alpha subunits indicating that GAPs deactivate the G-alpha subunits. RGSs increase GTP hydrolysis and then dissociate. This allows the formation of inactive G-protein heterotrimers by the association of G-alpha and G-beta subunits. These heterotrimers terminate the G-protein signal.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family
Article Abstract:
An RGS mammalian gene family substantially inhibits G-protein-regulated MAP kinase activation. The gene encodes functional and structural homologues of Sst2p. Southern blot analysis indicates that expression of RGS1, TGS2, RGS3 and RGS4 decreases pheromone sensitivity in a dose dependent manner. The G-protein alpha subunit is necessary for the functioning of RGS. The characteristics of Sst2p gene are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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The need for speed
Article Abstract:
The genetic and molecular mechanism of momentarily blindness is explained. Light- stimulation triggers phototransduction cascade reactions in neurons of eye that are responsible for visual perception.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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