RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
Article Abstract:
The human replication protein (RPA) appears to be essential for nucleotide excision repair through facilitating specific polypeptide protein-protein contacts. RPA is directly and particularly linked to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG. The RPA acts in the initial stage of excision repair as a cooperative complex of RPA and XPA which may allow the XPA to target the DNA lesions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Role of auxilin in uncoating clathrin-coated vesicles
Article Abstract:
A study has been conducted to examine the role of protein coat auxilin in uncoating clathrin-coated vesicles that transport selected membrane proteins from the clel surface to the endosomal system. The results showed that auxilin binds with high affinity to clathrin lattices to catalyze protein folding and protein transport across the cell membrane. Auxilin has also been shown to catalyze the selective disruption of protein-protein interactions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Cloning of a new cytokine that induces IFN-gamma production by T cells
Article Abstract:
The cloned IFN-gamma-inducing factor (IGIF) is a regulatory cytokine that activates the formation of IFN-gamma in the Th1 subset of the CD4+ T cells. Natural killer functioning is enhanced in the spleen cells by IGIF. Both a 192-amino acid precursor protein and a mature 157-amino acid protein are encoded by the gene. The IGIF regulates tissue damage in inflammatory reactions and development of Th1 cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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