RecA acts in trans to allow replication of damaged DNA by DNA polymerase V

Article Abstract:

The role of pol V in SOS DNA damage induced mutagenesis is analyzed and whether transactivation is required for pol V activity when the [beta]-prcoessivity clamp is included in the reaction is determined. It is suggested that trans-stimulation of pol V by RecA bound to SSDNA reflects a distinctive regulatory mechanism of mutation that resolves the paradox of RecA filaments assembled in cis on a damaged template strand obstructing translesion DNA synthesis despite the absolute requirement of RecA for SOS mutagenesis.

Indiana, Analysis, DNA damage, Bacterial proteins, Mutagenesis, DNA synthesis

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The structural basis of yeast prion strain variants

Article Abstract:

Several methodologies are utilized to analyze the various differences between different strain conformations of yeast prion. The results show that prion strains have large-scale conformational differences that alter their physiological impact.

Physiological aspects, Genetic aspects, Prions, Prions (Proteins), Yeast fungi, Yeasts (Fungi)

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