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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose

Article Abstract:

There is evidence that cyclic ADP-ribose (cADPR) is vital for long-term Ca2+ entry, which is significant for the generation of a functional immune response as T cells need the sustained Ca2+ signal for clonal expansion. It seems that cADPR has a direct modulatory impact on channel opening. The stimulatory effect of cADPR on the binding velocity of ryanodine is dose dependent and specific. This effect is reversed by various agonists of ryanodine receptor and of cADPR.

Author: Potter, Barry V.L., Weber, Karin, Schulze-Koops, Hendrik, Guse, Andreas H., Silva, Cristina P. da, Berg, Ingeborg, Skapenko, Alla L., Heyer, Petra, Hohenegger, Martin, Ashamu, Gloria A., Mayr, Georg W.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
Physiological aspects, Lymphocytes, Adenosine diphosphate

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InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase

Article Abstract:

A new study investigates the function of inositol 1,3,4,5-tetrakisphosphate (InsP4) in calcium influx in the mast cell line RBL-2H3. It is shown that it InsP4 inhibits metabolism of inositol 1,4,5-trisphosphate (InsP3) through InsP3 5-phosphatase.

Author: Hermosura, Meredith C., Takeuchi, Hiroshi, Fleig, Andrea, Riley, Andrew M.m, Potter, Barry V.L., Hirata, Masato, Penner, Reinhold
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Case studies, Biochemistry, Molecular biology, Inositol phosphates

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ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

Article Abstract:

Research examining the process of gating of free ADP-ribose intracellular signalling molecules of vertebrates is presented. Particular attention is given to the detection of native LTRPC2 functions in monocite cell lines such as U937.

Author: Fleig, Andrea, Perraud, Anne-Laure, Stokes, Alexander J., Dunn, Christpher A., Bagley, Leigh Ann, Launay, Pierre, Schmitz, Carsten
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Cases, Vertebrates, Cellular signal transduction, Animal anatomy

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Subjects list: Research, Cell research, Cytological research
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